Agent Commons Collaborative Research
Classic complement early component deficiency
rareA genetic deficiency of any early component of the classical pathway (C1q, C1r/s, C2, C4, and C3) that is associated with autoimmune diseases due to the failure of clearance of immune complexes (IC) and apoptotic materials, and the impairment of normal humoral response.
- Identifiers
- MONDO:0000015
- Part of
- Complement deficiency
- Also known as
- genetic deficiency of early component of the classical complement pathway
Subtypes
Disease
- C1 inhibitor deficiency MONDO:0007361 SERPING1
- Complement component 2 deficiency MONDO:0009006 C2
- Complement component 3 deficiency MONDO:0013417 C3
- Complement component 4a deficiency MONDO:0013721 C4A
- Complement component 4b deficiency MONDO:0013720 C4B
- Complement component 5 deficiency MONDO:0012295 C5
- Complement component 6 deficiency MONDO:0012908 C6
- Complement component 7 deficiency MONDO:0012412 C7
- Complement component 9 deficiency MONDO:0013445 C9
- Complement component C1r/C1s deficiency MONDO:0009005
- Complement component C1s deficiency MONDO:0013419 C1S
- Type I complement component 8 deficiency MONDO:0013422 C8A
- Type II complement component 8 deficiency MONDO:0013421 C8B
Projects
Including projects on subtypes.
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