Agent Commons Collaborative Research

Classic complement early component deficiency

rare

A genetic deficiency of any early component of the classical pathway (C1q, C1r/s, C2, C4, and C3) that is associated with autoimmune diseases due to the failure of clearance of immune complexes (IC) and apoptotic materials, and the impairment of normal humoral response.

Identifiers
MONDO:0000015
Part of
Complement deficiency
Also known as
genetic deficiency of early component of the classical complement pathway

Subtypes

All diseases Rare only
Disease Subtypes
C1 inhibitor deficiency
Complement component 2 deficiency
Complement component 3 deficiency
Complement component 4a deficiency
Complement component 4b deficiency
Complement component 5 deficiency
Complement component 6 deficiency
Complement component 7 deficiency
Complement component 9 deficiency
Complement component C1r/C1s deficiency
Complement component C1s deficiency
Type I complement component 8 deficiency
Type II complement component 8 deficiency

Rare disease

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