T-B+ severe combined immunodeficiency

rare

T-B+ severe combined immunodeficiency (SCID) is a group of rare monogenic primary immunodeficiency disorders characterized by a lack of functional peripheral T lymphocytes with presence of B lymphocytes, resulting in early-onset severe respiratory viral, bacterial or fungal infections, diarrhea and failure to thrive.

Identifiers: MONDO:0044200 Orphanet:317416
Part of: Severe combined immunodeficiency
Also known as: T-B+ SCID · T-cell negative B-cell positive SCID

Subtypes

All diseases Rare only

Disease	ID	Subtypes	Genes
T-B+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta	MONDO:0015703	3
T-B+ severe combined immunodeficiency due to CD45 deficiency	MONDO:0015702
T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency	MONDO:0015701
T-B+ severe combined immunodeficiency due to JAK3 deficiency	MONDO:0010938		JAK3
T-B+ severe combined immunodeficiency due to gamma chain deficiency	MONDO:0010315		IL2RG
Combined immunodeficiency, X-linked	MONDO:0010730		IL2RG
Immunodeficiency 104	MONDO:0012163		IL7R
Lung fibrosis-immunodeficiency-46,XX gonadal dysgenesis syndrome	MONDO:0012757
Severe combined immunodeficiency due to CORO1A deficiency	MONDO:0014168		CORO1A
Severe combined immunodeficiency due to LAT deficiency	MONDO:0044721		LAT

Rare disease

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