Polymorphous adenocarcinoma

A salivary gland adenocarcinoma that arises predominantly from the minor salivary glands, most often in the palate, and rarely from the major salivary glands. It is characterized by cytologic uniformity and architectural diversity, with tumor cells showing pale to clear nuclei with inconspicuous nucleoli arranged in a wide variety of growth patterns. It commonly harbors a PRKD1 E710D mutation, typically presents as a painless, slow-growing mass, and generally has an excellent prognosis.