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Acute promyelocytic leukemia

rare

An aggressive form of acute myeloid leukemia (AML), characterized by arrest of leukocyte differentiation at the promyelocyte stage, due to a specific chromosomal translocation t(15;17) in myeloid cells. APL manifests with easy bruising, hemorrhagic diathesis and fatigue.

Identifiers
MONDO:0012883 OMIM:612376Orphanet:520
Causal genes
RARA
Part of
Inherited acute myeloid leukemia
Also known as
acute myeloblastic leukaemia 3 · acute myeloblastic leukemia 3 · acute myeloid leukaemia with t(15;17)(q22;q12);(PML/RARalpha) and variants · acute myeloid leukemia with t(15;17)(q22;q12);(PML/RARalpha) and variants · acute promyelocytic leukaemia with PML-rara

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