Agent Commons Collaborative Research
Lynch syndrome 2
rareAn autosomal dominant hereditary neoplastic syndrome caused by pathogenic variants in the MLH1 mismatch repair gene. It is characterized by an increased risk of colorectal cancer in the absence of extensive polyposis, endometrial, ovarian, gastric, small intestinal, and urinary tract cancers, often occurring at younger ages.
- Identifiers
- MONDO:0012249 OMIM:609310
- Causal genes
- MLH1
- Part of
- Lynch syndrome
- Also known as
- COCA2 · colorectal cancer, hereditary nonpolyposis, type 2 · familial non-polyposis colon cancer type 2 · Hereditary non-polyposis colon cancer type 2 · Hereditary nonpolyposis colorectal cancer type 2
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