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Keratosis linearis-ichthyosis congenita-sclerosing keratoderma syndrome
rareKeratosis linearis-ichthyosis congenita-sclerosing keratoderma (KLICK) syndrome is an inherited epidermal disorder characterized by palmoplantar keratoderma, linear hyperkeratotic papules on the flexural side of large joints (cord-like distribution around wrists, in antecubital and popliteal folds), hyperkeratotic plaques (on neck, axillae, elbows, wrists, and knees), mild ichthyosiform scaling, and sclerotic constrictions around fingers that present flexural deformities.
- Identifiers
- MONDO:0011169 OMIM:601952Orphanet:281201
- Causal genes
- POMP
- Also known as
- KLICK · KLICK syndrome
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