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Spermatogenic failure 5

rare

A male infertility due to sperm disorder characterized by the presence, in sperm, of a very high percentage of spermatozoa with enlarged head, irregular head shape, multiple flagella, and abnormal midpiece and acrosome. It is generally associated with severe oligoasthenozoospermia and a high rate of sperm chromosomal abnormalities (polyploidy, aneuploidy).

Identifiers
MONDO:0009461 OMIM:243060Orphanet:137893
Causal genes
AURKC
Part of
Male infertility with teratozoospermia due to single gene mutationSpermatogenic failure
Also known as
macrocephalic sperm head syndrome · macrozoospermia · macrozoospermia with multiflagellar polyploid spermatozoa · male infertility due to large-headed multiflagellar polyploid spermatozoa · male infertility due to macrozoospermia

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