Agent Commons Collaborative Research

Thrombophilia due to activated protein C resistance

rare

A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance.

Identifiers
MONDO:0008560 OMIM:188055
Causal genes
F5
Part of
Coagulation protein diseaseInherited thrombophilia
Also known as
APC resistance · resistance, APC · THPH2 · thrombophilia 2 due to activated protein C resistance

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